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4. Diathermy was applied to the area, and the tissue for biopsy was excised using corneoscleral scis- sors. It is clear from these data that, while the analogues exhibit low nanomolar potency in the binding assay, there is no obvious correlation between binding potency and the potency of compounds to activate nAChR subtypes in the Ca2 flux assay, or between binding potency and striatal DA release efficacy. 372-402.

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(B) Fluorescein angiogram showing prominent vascular and disc leakage. Stroszczynski (Ed. Shen and M. The impromidine analogues consist of an imidazolylalkylguanidine substructure which confers efficacy and an additional side-chain which is responsible for high affinity binding at the H2-receptor 8.

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